Virtual Human Twins (VHTs) for integrated clinical decision support in prevention and diagnosis
EU-wide funding of research projects for the development and validation of multi-organ, multi-scale Digital Humans (VHTs) as integrated clinical decision support tools in prevention and diagnostics. Submission deadline: 22.09.2027.
Discover your potential with AI support
- Find out if this grant matches your project
- Develop your application together with AI
- Get matched with many more suitable grants
Grant criteria
Funding objective
Development, expansion, and validation of highly complex multi-organ and multi-scale computational models ("Virtual Human Twins") that provide individualized prevention and diagnostic tools in areas of high disease burden, including integration into clinical care pathways and linkage with additional diagnostic and preventive procedures.
Eligible expenses
- Personnel expenses
- Travel expenses
- Material costs
- Equipment costs
Non-eligible expenses
- Acquisition of real estate
- Retroactive costs
Eligible to apply
- Companies
- Educational Institutions
- Non-profit Organizations
- Public Institutions
Funding requirements
- Legal and financial capacity according to Horizon Europe Regulation
- Compliance with ethical and data protection standards
- International cooperation within the consortium
Documents required for application
- Project description
- Financing plan
- Curriculum vitae of the project leaders
- Ethics self-assessment
- Cover letter from the European Commission
Evaluation criteria
- Excellence of the research approach
- Expected impact
- Quality of implementation
Description
The European Union call supports the development and validation of highly complex, multi-organ and multi-scale Digital Human Twins (VHTs) as integrated clinical decision support tools in prevention and diagnostics with a total volume of €39.3 million. Research and innovation projects (Horizon Europe Research and Innovation Actions) with a project duration of up to 36 months are funded at a rate of 100%. The maximum funding amount per consortium ranges between €10 million and €12 million. Eligible applicants are companies, universities, non-profit and public institutions from EU member states or associated countries that are part of an interdisciplinary consortium of research institutions, clinics, AI developers, and SMEs in the health and biotech sector. Applications must be submitted electronically via the Funding & Tenders Portal by 22 September 2027.
The focus is on the design, expansion, and validation of patient-specific computational models to improve the prevention and early detection of diseases with high morbidity and mortality. The projects should address selected clinical use cases, represent multi-scale pathophysiology, and integrate VHTs into care pathways as well as complementary diagnostic procedures. Current standards, data sources (e.g., biobanks), and methods (biophysical modeling, explainable AI, generative approaches, agent-based simulation) must be included. Legal and financial capacity according to Horizon Europe regulations, compliance with ethical and data protection standards, and international consortium cooperation are required. The results must be clinically validated and provide evidence on application, cost-benefit, as well as regulatory and intellectual property aspects. Accompanying dissemination and exploitation plans, as well as engagement in the European Virtual Human Twins Initiative and the platform for Advanced VHT Models, complete the project.